KIAA1718 is a histone demethylase that erases repressive histone methyl marks

Atsushi Yokoyama, Yosuke Okuno, Toshihiro Chikanishi, Waka Hashiba, Hiroki Sekine, Ryoji Fujiki, Shigeaki Kato

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

The methylation states of histone lysine residues are regarded as significant epigenetic marks governing transcriptional regulation. A number of histone demethylases containing a jumonji C (JmjC) domain have been recognized; however, their properties remain to be investigated. Here, we show that KIAA1718, a PHF2/PHF8 subfamily member, possesses histone demethylase activity specific for H3K9 and H3K27, transcriptionally repressive histone marks. Biochemical purification of the KIAA1718 interactants reveals that KIAA1718 forms complexes with several factors including KAP1, a transcriptional co-activator. Consistent with these findings, KIAA1718 shows a transcriptional activation function in the chromatin context. Thus, our study identifies KIAA1718 as a histone demethylase for repressive methyl marks and shows that it is involved in transcriptional activation.

Original languageEnglish
Pages (from-to)867-873
Number of pages7
JournalGenes to Cells
Volume15
Issue number8
DOIs
Publication statusPublished - 2010 Aug
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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