Abstract
In Ca2+-free solution containing endothelin-1 (ET-1), depolarization by high KCl increased the force of contraction without any changes in intracellular calcium concentration ([Ca2+]i) in canine coronary artery. The [Ca2+]i-force relationships were examined in the absence or presence of ET-1 in 5 or 90 mM KCl. The relation curve in the presence of ET-1 in 90 mM KC1-PSS was shifted to the left and upward compared with that in 5 mM KCl. These results suggest that KCl-depolarization potentiates the Ca2+ sensitization by ET-1.
| Original language | English |
|---|---|
| Pages (from-to) | 403-405 |
| Number of pages | 3 |
| Journal | The Japanese Journal of Pharmacology |
| Volume | 60 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1992 Jan |
| Externally published | Yes |
Keywords
- Ca2+ sensitivity
- Endothelin-1
- KCl-depolarization
ASJC Scopus subject areas
- Pharmacology