KCl-Depolarization Potentiates the Ca Sensitization by Endothelin-1 in Canine Coronary Artery

Yuji Okada, Teruyuki Yanagisawa, Norio Taira

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

In Ca2+-free solution containing endothelin-1 (ET-1), depolarization by high KCl increased the force of contraction without any changes in intracellular calcium concentration ([Ca2+]i) in canine coronary artery. The [Ca2+]i-force relationships were examined in the absence or presence of ET-1 in 5 or 90 mM KCl. The relation curve in the presence of ET-1 in 90 mM KC1-PSS was shifted to the left and upward compared with that in 5 mM KCl. These results suggest that KCl-depolarization potentiates the Ca2+ sensitization by ET-1.

Original languageEnglish
Pages (from-to)403-405
Number of pages3
JournalThe Japanese Journal of Pharmacology
Volume60
Issue number4
DOIs
Publication statusPublished - 1992 Jan

Keywords

  • Ca2+ sensitivity
  • Endothelin-1
  • KCl-depolarization

ASJC Scopus subject areas

  • Pharmacology

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