K-ras point mutations in endometrial carcinoma: Effect on outcome is dependent on age of patient

Kiyoshi Ito, Keiko Watanabe, Suhail Nasim, Hironobu Sasano, Shinji Sato, Akira Yajima, Steven G. Silverberg, Carleton T. Garret

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37 Citations (Scopus)


Mutations involving the K-ras proto-oncogene are believed to play an important role in the mechanism of tumorigenesis for many human cancers and occur in 10-30% of endometrial carcinomas. In the present study 221 cases of endometrioid endometrial carcinoma obtained from Japanese patients with average follow-up of 41 months were examined for point mutations in codon 12 of K-ras through use of the polymerase chain reaction. In 103 cases lymph node dissection had been performed. K-ras mutations were significantly associated with the presence of lymph node metastases (P ≤ 0.04). Since endometrial carcinoma in premenopausal women generally behaves less aggressively than tumors of similar histologic grade arising in postmenopausal patients, we evaluated the effect of K-ras mutation on outcome in patients stratified into three different age categories (≤ 53 years, premenopausal; 54-59 years, perimenopausal; ≤60 years, postmenopausal). In the postmenopausal age group (≤60 years), the presence of K-ras mutations was statistically significantly associated with patients who died or experienced recurrence (41.2% vs 13.0%; P < 0.03). This was related to a dramatic (greater than eightfold; P = 0.011) increase in the likelihood of adverse outcome between the premenopausal and postmenopausal states for patients whose tumors contained mutant K-ras. These findings point to a possible role for K-ras activation in the mechanism(s) responsible for more aggressive clinical behavior of endometrioid endometrial cancer that is observed in postmenopausal patients.

Original languageEnglish
Pages (from-to)238-246
Number of pages9
JournalGynecologic Oncology
Issue number2
Publication statusPublished - 1996 Nov

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology


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