TY - JOUR
T1 - Juvenile granulosa cell tumor discovered during pregnancy
T2 - Case report with immunohistochemical study of steroidogenesis
AU - Sasano, Hironobu
AU - Imaizumi, Hideaki
AU - Nagura, Hiroshi
PY - 1997
Y1 - 1997
N2 - A multilobular cystic juvenile granulosa cell tumor in a 33-year-old pregnant woman was examined. Pathological examination of the specimen at Cesarian section at 38 weeks of gestation revealed three different histological patterns; diffuse proliferation, trabecular or cord-like proliferation, and characteristic microfollicular patterns, as well as the presence of numerous luteinized stromal cells. These histological patterns were intermingled and transference among these patterns was detected. Immunoreactivity of steroidogenic enzymes including cholesterol side-chain cleavage, 3β-hydroxysteroid dehydrogenase and 17α-hydroxylase was detected only in luteinized stromal cells. However, that of adrenal 4 binding protein, a transcription factor of steroidogenesis, was present in almost all the tumor cells as well as luteinized stromal cells, suggesting that tumor cells acquired the potential of metabolizing and synthesizing steroid hormones. The hormonal environment associated with pregnancy altered the histological and biological features of this juvenile granulosa cell factor.
AB - A multilobular cystic juvenile granulosa cell tumor in a 33-year-old pregnant woman was examined. Pathological examination of the specimen at Cesarian section at 38 weeks of gestation revealed three different histological patterns; diffuse proliferation, trabecular or cord-like proliferation, and characteristic microfollicular patterns, as well as the presence of numerous luteinized stromal cells. These histological patterns were intermingled and transference among these patterns was detected. Immunoreactivity of steroidogenic enzymes including cholesterol side-chain cleavage, 3β-hydroxysteroid dehydrogenase and 17α-hydroxylase was detected only in luteinized stromal cells. However, that of adrenal 4 binding protein, a transcription factor of steroidogenesis, was present in almost all the tumor cells as well as luteinized stromal cells, suggesting that tumor cells acquired the potential of metabolizing and synthesizing steroid hormones. The hormonal environment associated with pregnancy altered the histological and biological features of this juvenile granulosa cell factor.
KW - ovary
KW - pregnancy
KW - sex cord-stromal tumor
KW - steroidogenesis
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U2 - 10.1111/j.1440-1827.1997.tb04501.x
DO - 10.1111/j.1440-1827.1997.tb04501.x
M3 - Article
C2 - 9143029
AN - SCOPUS:0031002071
VL - 47
SP - 325
EP - 328
JO - Acta Pathologica Japonica
JF - Acta Pathologica Japonica
SN - 1320-5463
IS - 5
ER -