Abstract
In the course of our screening program for active compounds from fungal metabolites, we isolated JBIR-12 (1) as a free radical scavenger from the culture broth of Penicillium sp. NBRC 103941. Structure elucidation of 1 was carried out using methylated and/or acetylated derivatives of 1. As a consequence, the structure of 1 was determined to be a novel highly oxygenated tetrahydronaphthalene species attached to an acyl chain moiety on the basis of NMR and other spectroscopic data. It was interesting that 1 was spontaneously methylated when left in methanol. Furthermore, isomerization or rearrangements could occur during the derivatization of 1. Compound 1 exhibited potent radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl radical with an IC"5"0 value of 75 μM.
Original language | English |
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Pages (from-to) | 177-180 |
Number of pages | 4 |
Journal | Journal of Antibiotics |
Volume | 62 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2009 Apr |
Keywords
- Antioxidative agent
- JBIR-12
- Penicillium sp.
- Radical scavenging
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery