JBIR-12, a novel antioxidative agent from Penicillium sp. NBRC 103941

Miho Izumikawa, Aya Nagai, Takayuki Doi, Motoki Takagi, Kazuo Shin-Ya

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


In the course of our screening program for active compounds from fungal metabolites, we isolated JBIR-12 (1) as a free radical scavenger from the culture broth of Penicillium sp. NBRC 103941. Structure elucidation of 1 was carried out using methylated and/or acetylated derivatives of 1. As a consequence, the structure of 1 was determined to be a novel highly oxygenated tetrahydronaphthalene species attached to an acyl chain moiety on the basis of NMR and other spectroscopic data. It was interesting that 1 was spontaneously methylated when left in methanol. Furthermore, isomerization or rearrangements could occur during the derivatization of 1. Compound 1 exhibited potent radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl radical with an IC"5"0 value of 75 μM.

Original languageEnglish
Pages (from-to)177-180
Number of pages4
JournalJournal of Antibiotics
Issue number4
Publication statusPublished - 2009 Apr


  • Antioxidative agent
  • JBIR-12
  • Penicillium sp.
  • Radical scavenging

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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