Japanese and non-Japanese patients with transient ischemic attack or minor stroke: A five-year risk analysis of stroke and vascular events

Shinichiro Uchiyama, Takao Hoshino, Hugo Charles, Kenji Kamiyama, Taizen Nakase, Kazuo Kitagawa, Kazuo Minematsu, Kenichi Todo, Yasushi Okada, Jyoji Nakagawara, Ken Nagata, Hiroshi Yamagami, Takenori Yamaguchi, Pierre Amarenco

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Aims: We have previously reported 5-year follow-up data on the TIAregistry.org, an international prospective cohort in patients with transient ischemic attack (TIA) or minor stroke. We conducted a Japanese subgroup analysis because outcomes and predictors might differ according to ethnicities and regions. In this study, we compared the baseline and 5-year follow-up data of Japanese and non-Japanese patients with TIA or minor stroke. Methods: Patients with TIA or minor ischemic stroke within 7 days after the onset were classified into two groups based on ethnicity, Japanese (n=345) and non-Japanese (n=3502); further, 5-year event rates were compared between the two groups. We also determined predictors of 5-year stroke for both groups. Results: Vascular death and death from any cause were identified to be less prevalent, unlike stroke and intracranial hemorrhage, which was determined to be more prevalent in Japanese than in non-Japanese patients. Five-year rate of stroke was significantly higher in Japanese patients. Cumulative stroke and major cardiovascular event rates did not decline but instead linearly increased from 1 to 5 years in both groups. Baseline risk factors for 5-year stroke were as follows: age, diabetes, history of stroke or TIA, and congestive heart failure in Japanese patients. Independent predictors of 5-year stroke were large artery atherosclerosis, congestive heart failure, diabetes, and age in Japanese patients. Conclusions: Recurrent stroke and intracranial hemorrhage were determined to be more prevalent at 5 years after TIA or minor stroke in Japanese patients than in non-Japanese patients. Strategies to mitigate the long-term risks of stroke, aside from adherence to current guidelines, should take Japanese-patient-specific residual risks into account.

Original languageEnglish
Pages (from-to)656-664
Number of pages9
JournalJournal of atherosclerosis and thrombosis
Issue number6
Publication statusPublished - 2021
Externally publishedYes


  • Outcome
  • Predictor
  • Risk factor
  • Stroke
  • Transient ischemic attack

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Biochemistry, medical


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