Jacaric acid is rapidly metabolized to conjugated linoleic acid in rats

Ryo Kijima, Taro Honma, Junya Ito, Masao Yamasaki, Aya Ikezaki, Chihiro Motonaga, Kazuo Nishiyama, Tsuyoshi Tsuduki

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

We have shown previously that jacaric acid (JA; 8c,10t,12c-18:3), which has a conjugated triene system, has a strong anti-tumor effect. However, the characteristics of absorption and metabolism of JA have yet to be determined in vivo, and the details of absorption and metabolism of JA in the small intestine are particularly unclear. This information is required for effective use of JA in humans. Therefore, in this study we examined absorption and metabolism of JA using cannulation of the thoracic duct in rats. Emulsions of two test oils, jacaranda seed oil and tung oil, which contain JA and α-eleostearic acid (α-ESA; 9c,11t,13t-18:3), respectively, were administered to rats and lymph from the thoracic duct was collected over 24 h. We examined the rate of absorption of JA and possible conversion to a conjugated linoleic acid (CLA)containing a conjugated diene system. The positional isomerism of the CLA produced by JA metabolism was determined using gas chromatography-electron impact/mass spectrometry. The rate of absorption and percentage conversion of JA were compared with those of α-ESA. We found that JA is rapidly absorbed and converted to a CLA in rats and that the percentage conversion of JA was lower than that of α-ESA. This is the first report on the absorption and metabolism of JA and this information may be important for application of JA as a functional food.

Original languageEnglish
Pages (from-to)305-312
Number of pages8
JournalJournal of oleo science
Volume62
Issue number5
DOIs
Publication statusPublished - 2013 May 2

Keywords

  • Conjugated fatty acid
  • Conjugated linoleic acid
  • Conjugated linolenic acid
  • Jacaric acid
  • Lymph

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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