Isthmus organizer for mesencephalon and metencephalon

Harukazu Nakamura; Tatsuya Sato; Asuka Suzuki-Hirano

doi:10.1111/j.1440-169X.2008.00995.x

Isthmus organizer for mesencephalon and metencephalon

Harukazu Nakamura, Tatsuya Sato, Asuka Suzuki-Hirano

Research output: Contribution to journal › Review article › peer-review

51 Citations (Scopus)

Abstract

The vertebrate central nervous system is elaborated from a simple neural tube. Brain vesicles formation is the first sign of regionalization. Classical transplantation using quail and chick embryos revealed that the mesencephalon-metencephalon boundary (isthmus) functions as an organizer of the mesencephalon and metencephalon. Fgf8 is accepted as a main organizing molecule of the isthmus. Strong Fgf8 signal activates the Ras-ERK signaling pathway to differentiate the cerebellum. In this review, the historical background of the means of identifying the isthmus organizer and the molecular mechanisms of signal transduction for tectum and cerebellum differentiation is reviewed.

Original language	English
Pages (from-to)	S113-S118
Journal	Development Growth and Differentiation
Volume	50
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1111/j.1440-169X.2008.00995.x
Publication status	Published - 2008 Jun 1
Externally published	Yes

Keywords

Cerebellum
Fgf8
Isthmus organizer
Ras-ERK pathway
Tectum

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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10.1111/j.1440-169X.2008.00995.x

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AU - Nakamura, Harukazu

AU - Sato, Tatsuya

AU - Suzuki-Hirano, Asuka

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N2 - The vertebrate central nervous system is elaborated from a simple neural tube. Brain vesicles formation is the first sign of regionalization. Classical transplantation using quail and chick embryos revealed that the mesencephalon-metencephalon boundary (isthmus) functions as an organizer of the mesencephalon and metencephalon. Fgf8 is accepted as a main organizing molecule of the isthmus. Strong Fgf8 signal activates the Ras-ERK signaling pathway to differentiate the cerebellum. In this review, the historical background of the means of identifying the isthmus organizer and the molecular mechanisms of signal transduction for tectum and cerebellum differentiation is reviewed.

AB - The vertebrate central nervous system is elaborated from a simple neural tube. Brain vesicles formation is the first sign of regionalization. Classical transplantation using quail and chick embryos revealed that the mesencephalon-metencephalon boundary (isthmus) functions as an organizer of the mesencephalon and metencephalon. Fgf8 is accepted as a main organizing molecule of the isthmus. Strong Fgf8 signal activates the Ras-ERK signaling pathway to differentiate the cerebellum. In this review, the historical background of the means of identifying the isthmus organizer and the molecular mechanisms of signal transduction for tectum and cerebellum differentiation is reviewed.

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KW - Isthmus organizer

KW - Ras-ERK pathway

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