Isopoly-L-Ornithine derivatives of thymine and thymidine

Yoshiaki Inaki, Norimitsu Tohnai, Keiko Miyabayashi, Takehiko Wada, Mikiji Miyata

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

L-Ornithine derivatives of thymine, and thymidine gave oligomers by solid phase elongation reactions. These oligomers 2 and 3, however, hardly interact with the complementary polynucleotide. Conformational studies of the oligomers with CD and NMR revealed that stable intramolecular hydrogen bonding was formed between thymine base and ornithine unit.

Original languageEnglish
Pages (from-to)339-350
Number of pages12
JournalNucleosides and Nucleotides
Volume17
Issue number1-3
Publication statusPublished - 1998 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Genetics

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  • Cite this

    Inaki, Y., Tohnai, N., Miyabayashi, K., Wada, T., & Miyata, M. (1998). Isopoly-L-Ornithine derivatives of thymine and thymidine. Nucleosides and Nucleotides, 17(1-3), 339-350.