Isopimarane diterpene glycosides, isolated from endophytic fungus Paraconiothyrium sp. MY-42

Yoshihito Shiono, Miwako Kikuchi, Takuya Koseki, Tetsuya Murayama, Eunsang Kwon, Nobuhiro Aburai, Ken Ichi Kimura

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Six isopimarane diterpenes, compounds 1-6, were isolated from the endophytic fungus Paraconiothyrium sp. MY-42. Compound 1 possesses a 19-glucopyranosyloxy group. Its structure was first elucidated by spectroscopic data analysis and finally confirmed by X-ray crystallography, whereas structures 2-6 were mainly elucidated based on the analysis of spectroscopic evidence. Compounds 2 and 3 showed moderate cytotoxicities against the human promyelocytic leukemia cell line HL60 (IC50 6.7 μM value for 2 and 9.8 μM for 3).

Original languageEnglish
Pages (from-to)1400-1405
Number of pages6
JournalPhytochemistry
Volume72
Issue number11-12
DOIs
Publication statusPublished - 2011 Aug

Keywords

  • Cytotoxicity
  • Endophytic fungus
  • Isopimarane diterpenes
  • Paraconiothyrium sp.

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

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