Isomer-specific anti-obese and hypolipidemic properties of conjugated linoleic acid in obese OLETF rats

Yu Ming Wang, Koji Nagao, Nao Inoue, Yoko Ujino, Yuji Shimada, Toshihiro Nagao, Toshio Iwata, Takeshi Kamegai, Yoshie Yamauchi-Sato, Teruyoshi Yanagita

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)


Conjugated linoleic acid (CLA), a mixture of positional and geometric isomers of linoleic acid, has attracted considerable attention because of its potentially beneficial biologic effects both in vitro and in vivo. Our results clearly show the specific action of the 10trans,12cis-CLA isomer against hyperlipidemia and obesity in obese Otsuka Long-Evans Tokushima Fatty (OLETF) rats. After 2 weeks of feeding with 10t,12c-CLA, but not 9cis,11trans-CLA, abdominal adipose tissue weight and serum and hepatic lipid levels in OLETF rats were lower than those in linoleic acid-fed rats. These effects were attributable to suppressed fatty acid synthesis and enhanced fatty acid beta oxidation in the liver on a 10t,12c-CLA diet. Additionally, we showed that mRNA expression of fatty acid synthase, carnitine palmitoyltransferase, leptin, and sterol regulatory element binding protein-1 was also regulated by 10t,12c-CLA. We suppose that 10t,12c-CLA reveals hypolipidemic and anti-obese activity through the alteration of mRNA expressions in the liver and white adipose tissue.

Original languageEnglish
Pages (from-to)355-362
Number of pages8
JournalBioscience, Biotechnology and Biochemistry
Issue number2
Publication statusPublished - 2006
Externally publishedYes


  • Conjugated linoleic acid isomers
  • Hyperlipidemia
  • Obesity
  • Otsuka Long-Evans Tokushima Fatty rat
  • Sterol regulatory element binding protein-1

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry


Dive into the research topics of 'Isomer-specific anti-obese and hypolipidemic properties of conjugated linoleic acid in obese OLETF rats'. Together they form a unique fingerprint.

Cite this