Isoliquiritigen enhances antitumour activity of cyclophosphamid

Xuan Yuan, Defang Li., Hongmei Chen, Chao Sun, Na Chen, Xiaoyu Chen, Zhenhua Wang, Qiusheng Zheng

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    2 Citations (Scopus)

    Abstract

    Previous reports reveal that Isoliquiritigen(ISL), a licorice flavonoid, possesses various antitumour properties, cyclophosphamide, an alkylating agent, has various genotoxic and carcinogenic effects, and to be involved in some secondary neoplasmas. However, it is still used extensively as an antitumour agent and immunosuppressant in the clinic. In order to find out whether isoliquiritigen could enhance antitumour activity, as well as decrease genotoxic effects of cyclophosphamide or not, the antitumour activity and genotoxic effect of oral intake of ISL combined with intraperitoneal injection of cyclophosphamide was investigated. Mice bearing mouse sarcoma S180 cells and cervical cancer U14 cells were respectively used to estimate the antitumour activity in vivo. The clastogenic activity in bone marrow polychromatic erythrocytes was assayed by frequency of micronucleus. The DNA damage in peripheral white blood cells was assayed by single cell gel electrophoresis. The results indicated that oral administration of ISL (5, 10 and 20 mg/kg body weight) alone has no obvious antitumour activity and genotoxic effect in mice, while ISL synergistically enhanced the antitumour activity of cyclophosphamide (40 mg/kg body weight) in a dose-dependent manner. in addition, ISL can decrease the micronucleus formation in polychromatic erythrocytes and DNA strand breaks in white blood cells in a dose-dependent way. Our results suggested that ISL is able to enhance the antitumour activity and decrease the genotoxic effect of cyclophosphamide.

    Original languageEnglish
    Title of host publicationICBBT 2010 - 2010 International Conference on Bioinformatics and Biomedical Technology
    Pages172-175
    Number of pages4
    DOIs
    Publication statusPublished - 2010
    Event2010 International Conference on Bioinformatics and Biomedical Technology, ICBBT 2010 - Chengdu, China
    Duration: 2010 Apr 162010 Apr 18

    Publication series

    NameICBBT 2010 - 2010 International Conference on Bioinformatics and Biomedical Technology

    Conference

    Conference2010 International Conference on Bioinformatics and Biomedical Technology, ICBBT 2010
    CountryChina
    CityChengdu
    Period10/4/1610/4/18

    Keywords

    • Antitumour
    • Cyclophosphamide
    • Genotoxic Effect
    • Isoliquiritigenin

    ASJC Scopus subject areas

    • Biomedical Engineering
    • Health Informatics
    • Health Information Management

    Fingerprint Dive into the research topics of 'Isoliquiritigen enhances antitumour activity of cyclophosphamid'. Together they form a unique fingerprint.

    Cite this