TY - JOUR
T1 - Isolation, Synthesis, and Biological Activity of Chlorinated Alkylresorcinols from Dictyostelium Cellular Slime Molds
AU - Kikuchi, Haruhisa
AU - Ito, Ikuko
AU - Takahashi, Katsunori
AU - Ishigaki, Hirotaka
AU - Iizumi, Kyoichi
AU - Kubohara, Yuzuru
AU - Oshima, Yoshiteru
N1 - Funding Information:
This work was supported in part by the Grants-in-Aid for Scientific Research (no. 16H03279) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan; the Platform Project for Supporting Drug Discovery and Life Science Research funded by Japan Agency for Medical Research and Development (AMED); the Shorai Foundation for Science and Technology; Kobayashi International Scholarship Foundation; and the Takeda Science Foundation.
PY - 2017/10/27
Y1 - 2017/10/27
N2 - Eight chlorinated alkylresorcinols, monochasiol A-H (1-8), were isolated from the fruiting bodies of Dictyostelium monochasioides. Compounds 1-8 were synthesized to confirm their structures and to obtain sufficient material for performing biological tests. Monochasiol A (1) selectively inhibited the concanavalin A-induced interleukin-2 production in Jurkat cells, a human T lymphocyte cell line. Monochasiols were biogenetically synthesized by the combination of biosynthetic enzymes relating to the principal polyketides, MPBD and DIF-1, produced by Dictyostelium discoideum.
AB - Eight chlorinated alkylresorcinols, monochasiol A-H (1-8), were isolated from the fruiting bodies of Dictyostelium monochasioides. Compounds 1-8 were synthesized to confirm their structures and to obtain sufficient material for performing biological tests. Monochasiol A (1) selectively inhibited the concanavalin A-induced interleukin-2 production in Jurkat cells, a human T lymphocyte cell line. Monochasiols were biogenetically synthesized by the combination of biosynthetic enzymes relating to the principal polyketides, MPBD and DIF-1, produced by Dictyostelium discoideum.
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U2 - 10.1021/acs.jnatprod.7b00456
DO - 10.1021/acs.jnatprod.7b00456
M3 - Article
C2 - 28921976
AN - SCOPUS:85032574180
VL - 80
SP - 2716
EP - 2722
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 10
ER -