Isolation, Structure Determination, and Synthesis of Neodysiherbaine A, a New Excitatory Amino Acid from a Marine Sponge

Ryuichi Sakai, Tatsuki Koike, Makoto Sasaki, Keiko Shimamoto, Chie Oiwa, Atsuko Yano, Katsuji Suzuki, Kazuo Tachibana, Hisao Kamiya

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

matrix presented 2 : neodysiherbaine A A new excitatory amino acid, neodysiherbaine A (2), was isolated as a minor constituent of the aqueous extract from the marine sponge Dysidea herbacea. The structure was deduced by spectroscopic methods and established unambiguously by the total synthesis. The present synthesis, including as a key step cross-coupling of the 6/5-bicyclic core with an amino acid residue, is useful in constructing its structural analogues.

Original languageEnglish
Pages (from-to)1479-1482
Number of pages4
JournalOrganic letters
Volume3
Issue number10
DOIs
Publication statusPublished - 2001 May 17
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Isolation, Structure Determination, and Synthesis of Neodysiherbaine A, a New Excitatory Amino Acid from a Marine Sponge'. Together they form a unique fingerprint.

  • Cite this

    Sakai, R., Koike, T., Sasaki, M., Shimamoto, K., Oiwa, C., Yano, A., Suzuki, K., Tachibana, K., & Kamiya, H. (2001). Isolation, Structure Determination, and Synthesis of Neodysiherbaine A, a New Excitatory Amino Acid from a Marine Sponge. Organic letters, 3(10), 1479-1482. https://doi.org/10.1021/ol015798l