Isolation and structure determination of lysiformine from bacteria associated with marine sponge Halichondria okadai

Sou Kikuchi, Kayo Okada, Yuko Cho, Shinichiro Yoshida, Eunsang Kwon, Mari Yotsu-Yamashita, Keiichi Konoki

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Marine sponge Halichondria okadai is a source of numerous toxic secondary metabolites, which are considered as products of the symbiotic species associated with the sponge. In this study, we tested 720 culture conditions and purified 48 sponge-associated microbes. The ethyl acetate extract from the liquid culture of each species was tested for cytotoxicity, hemolytic activity, and brine shrimp lethal activity. Lysiformine (1) was isolated from Lysinibacillus fusiformis and its structure was determined by HRMS and NMR.

Original languageEnglish
Pages (from-to)3742-3747
Number of pages6
JournalTetrahedron
Volume74
Issue number27
DOIs
Publication statusPublished - 2018 Jul 5

Keywords

  • Halichondria okadai
  • Isolation
  • Lysinibacillus fusiformis
  • Structure determination

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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