Isolation and characterization of a cDNA encoding a new type of human transcription elongation factor S-II

Takashi Umehara, Satoshi Kida, Tohru Yamamoto, Masami Horikoshi

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

We report the isolation of a cDNA encoding a new type of transcription factor S-II, termed h-SII-T1, from a human library. The mRNA corresponding to the clone is highly expressed in testis and ovary. Comparison of the deduced amino acid (aa) sequence with those of other S-II molecules shows that (i) the C-terminal zinc finger (Zf) domain is highly conserved, and (ii) the central segment is most similar to that of the rat testis-specific S-II. Further analyses of the hS-II-T1 aa sequence indicate that its N-terminal sequence exhibits similarity to eubacterial σ54. The significance of tissue-specific S-II molecules for the regulation of transcription elongation is discussed.

Original languageEnglish
Pages (from-to)297-302
Number of pages6
JournalGene
Volume167
Issue number1-2
DOIs
Publication statusPublished - 1995 Dec 29

Keywords

  • Antitermination
  • RNA polymerase II
  • RPB9
  • pausing
  • sigma similarity

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'Isolation and characterization of a cDNA encoding a new type of human transcription elongation factor S-II'. Together they form a unique fingerprint.

Cite this