Abstract
We report the isolation of a cDNA encoding a new type of transcription factor S-II, termed h-SII-T1, from a human library. The mRNA corresponding to the clone is highly expressed in testis and ovary. Comparison of the deduced amino acid (aa) sequence with those of other S-II molecules shows that (i) the C-terminal zinc finger (Zf) domain is highly conserved, and (ii) the central segment is most similar to that of the rat testis-specific S-II. Further analyses of the hS-II-T1 aa sequence indicate that its N-terminal sequence exhibits similarity to eubacterial σ54. The significance of tissue-specific S-II molecules for the regulation of transcription elongation is discussed.
Original language | English |
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Pages (from-to) | 297-302 |
Number of pages | 6 |
Journal | Gene |
Volume | 167 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - 1995 Dec 29 |
Externally published | Yes |
Keywords
- Antitermination
- RNA polymerase II
- RPB9
- pausing
- sigma similarity
ASJC Scopus subject areas
- Genetics