Islet Amyloid Polypeptide has No Effect on Amylase Release from Rat Pancreatic Acini Stimulated by CCK-8, Secretin, Carbachol and VIP

Yoshifumi Kikuchi, Masaru Koizumi, Tooru Shimosegawa, Jyunya Kashimura, Susumu Suzuki, Takayoshi Toyota

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Islet amyloid polypeptide (IAPP), a novel peptide recently isolated from the amyloid substance of pancreatic islets, has been localized in normal islet B cell granules, suggesting its physiological action in exocrine pancreatic function. In the present study, the direct effect of IAPP on secretagogue-stimulated pancreatic enzyme secretion was investigated using dispersed rat pancreatic acini. Various concentrations of IAPP (10-5-10-10 M) showed no significant influence on amylase release stimulated either by submaximal doses of CCK-8 (10-11 M), secretin (0.5x 10-6 M) or carbachol (10-6 M), or by a maximal dose of vasoactive intestinal peptide (10-8 M). These results may provide negative evidence for a physiological significance of IAPP in rat pancreatic enzyme secretion.

Original languageEnglish
Pages (from-to)41-48
Number of pages8
JournalTohoku Journal of Experimental Medicine
Volume165
Issue number1
DOIs
Publication statusPublished - 1991 Jan 1

Keywords

  • IAPP
  • exocrine pancreas
  • rat pancreatic acini

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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