Ischemia/reperfusion of unilateral kidney exaggerates aging-induced damage to the heart and contralateral kidney

Junichiro Kato, Masaaki Nakayama, Wan Jun Zhu, Takashi Yokoo, Sadayoshi Ito

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Aims: We aimed to determine the impact of aging on ischemic acute kidney injury, especially in terms of the pathological mechanisms of kidney and heart crosstalk. Method: The effects of 45 min of unilateral ischemic reperfusion (IR) of the renal artery on the contralateral kidney and heart were histologically assessed in 7-and 40-week-old SD rats after 7 days. Results: Glomerular sclerosis, interstitial fibrosis and numbers of ED1 cells were significantly increased in the contralateral kidneys of the 40-, but not the 7-week-old rats. The numbers of ED1 cells in the heart significantly and similarly increased in both groups, but reactive fibrosis after IR was significant only in the 40-week-old rats. The exaggerated profibrotic response induced by aging seemed to be closely associated with the increased number of ED1 cells in the affected area. Conclusion: Aging could play a major role in exaggerating the pathological processes of inflammation to fibrosis in remote organs including the heart and the nonischemic kidney after IR stimulation of the unilateral kidney.

Original languageEnglish
Pages (from-to)183-190
Number of pages8
JournalNephron - Experimental Nephrology
Issue number4
Publication statusPublished - 2014 Jul


  • Cardiovascular diseases
  • Fibrosis
  • Inflammation
  • Macrophage infiltration

ASJC Scopus subject areas

  • Physiology
  • Genetics
  • Nephrology


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