Is vasohibin-1 for more than angiogenesis inhibition?

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16 Citations (Scopus)

Abstract

Angiogenesis, a formation of neo-vessels from pre-existing ones, is regulated by the local balance between its stimulators and inhibitors. Vasohibin-1 (VASH1) was originally identified as an endothelium-derived vascular endothelial growth factor (VEGF)-inducible angiogenesis inhibitor that acts in a negative feedback manner. The expression of VASH1 has been shown in endothelial cells (ECs) in both physiological and pathological conditions associated with angiogenesis. However, recent reports indicate that VASH1 is expressed not only in ECs but also in other cell types including haematopoietic cells. The function of VASH1 may not be restricted to angiogenesis inhibition.

Original languageEnglish
Pages (from-to)229-230
Number of pages2
JournalJournal of biochemistry
Volume149
Issue number3
DOIs
Publication statusPublished - 2011 Mar

Keywords

  • Angiogenesis
  • Bone Marrow
  • Endothelium
  • FeedbackHematopoiesis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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