Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases?

George Perry, Akihiko Nunomura, Keisuke Hirai, Xiongwei Zhu, Mar Prez, Jess Avila, Rudolph J. Castellani, Craig S. Atwood, Gjumrakch Aliev, Lawrence M. Sayre, Atsushi Takeda, Mark A. Smith

Research output: Contribution to journalArticlepeer-review

248 Citations (Scopus)

Abstract

In less than a decade, beginning with the demonstration by Floyd, Stadtman, Markesbery et al. [1] of increased reactive carbonyls in the brains of patients with Alzheimer's disease (AD), oxidative damage has been established as a feature of the disease. Here, we review the types of oxidative damage seen in AD, sites involved, possible origin, relationship to lesions, and compensatory changes, and we also consider other neurodegenerative diseases where oxidative stress has been implicated. Although much data remain to be collected, the broad spectrum of changes found in AD are only seen, albeit to a lesser extent, in normal aging with other neurodegenerative diseases showing distinct spectrums of change.

Original languageEnglish
Pages (from-to)1475-1479
Number of pages5
JournalFree Radical Biology and Medicine
Volume33
Issue number11
DOIs
Publication statusPublished - 2002 Dec 1

Keywords

  • Alzheimer's disease
  • Amyloid-β
  • Antioxidants
  • Free radicals
  • Homeostasis
  • Neurofibrillary tangles
  • Oxidative stress
  • Redox balance
  • Senile plaque
  • τ

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

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