Is Imprint Cytology Useful to Diagnose Malignancy for Brenner Tumors? A Case Series at a Single Institute

Junko Minato, Hideki Tokunaga, Satoshi Okamoto, Yusuke Shibuya, Hitoshi Niikura, Nobuo Yaegashi

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The aim of this study was to investigate cytological features of Brenner tumors according to tumor grade using imprint cytology. Case: Between 2004 and 2015, intraoperative imprint cytology was performed on 8 patients with Brenner tumors suspected to be malignant neoplasmas on gross examination because of their large size and solid part. These consisted of 1 benign, 3 borderline, and 4 malignant tumors. In patients with benign and borderline tumors, naked nucleus-like stromal cells and tumor cells in a sheet-like arrangement were observed against a clear background. The nuclei were round to oval-shaped with finely granular chromatin patterns and small nucleoli. Papillary cell clusters and high nucleus-to-cytoplasm ratios were only observed in 1 borderline case. In cases with malignancy, the background was necrotic. The tumor cells occurred in large papillary clusters. The nuclei showed a high degree of nuclear atypia. Nuclear grooves were present in 6 of our 8 cases and they were scant in the malignant cases. Conclusion: Imprint cytology of Brenner tumors provided no characteristic findings to enable a definitive distinction of benign versus borderline tumors, but it enabled discrimination between malignant and other tumors. Imprint cytology can facilitate intraoperative diagnosis and aid in selecting the appropriate surgical procedure.

Original languageEnglish
Pages (from-to)153-159
Number of pages7
JournalActa Cytologica
Volume61
Issue number2
DOIs
Publication statusPublished - 2017 May 1

Keywords

  • Brenner tumor
  • Imprint cytology
  • Ovary

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Fingerprint

Dive into the research topics of 'Is Imprint Cytology Useful to Diagnose Malignancy for Brenner Tumors? A Case Series at a Single Institute'. Together they form a unique fingerprint.

Cite this