Is distal pancreatectomy with en-bloc celiac axis resection effective for patients with locally advanced pancreatic ductal adenocarcinoma? -Multicenter surgical group study

Tomohisa Yamamoto, Sohei Satoi, Manabu Kawai, Fuyuhiko Motoi, Masayuki Sho, Ken ichiro Uemura, Ippei Matsumoto, Goro Honda, Ken ichi Okada, Takahiro Akahori, Hirochika Toyama, Masanao Kurata, Hiroaki Yanagimoto, Hiroki Yamaue, Michiaki Unno, Masanori Kon, Yoshiaki Murakami

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objectives: We retrospectively investigated the operative outcomes of patients who underwent distal pancreatectomy (DP) for invasive pancreatic ductal adenocarcinoma (PDAC) located at the body and tail. Methods: Data from 395 patients with PDAC who underwent DP with margin-negative resection (R0 or R1) were collected from seven high-volume centers in Japan from 2001 to 2012. Among them, 72 patients underwent DP with en-bloc celiac axis resection (DP-CAR). The remaining 323 patients underwent conventional DP with splenectomy (DP-S). To determine the efficacy of DP-CAR, clinicopathological data were compared between the DP-CAR and the DP-S groups. Results: The DP-S group consisted mainly of patients with resectable disease (93%), and conversely, all patients in the DP-CAR group had borderline resectable or unresectable disease. The overall morbidity was significantly higher in the DP-CAR group than in the DP-S group (63% vs 47%, respectively; P = 0.017). The median survival time (MST) of the DP-CAR group was significantly shorter than that of the DP-S group (17.5 vs 28.6 months, respectively; P = 0.004). However, the MST of patients in the DP-CAR group (n = 61, 85%) who received adjuvant therapy was significantly longer than that of patients in the DP-S group (n = 65, 20%) who underwent R1 resection (21.9 vs 16.7 months, respectively; P = 0.024). Conclusion: DP-CAR followed by adjuvant chemotherapy provided an acceptable overall survival rate in patients with highly advanced PDAC, but should be performed with great caution because of high morbidity. Patients with a high risk of positive surgical margins with DP-S may be candidates for DP-CAR.

Original languageEnglish
Pages (from-to)106-113
Number of pages8
JournalPancreatology
Volume18
Issue number1
DOIs
Publication statusPublished - 2018 Jan

Keywords

  • DP-CAR
  • Locally advanced PDAC
  • Overall survival
  • Pancreatic ductal adenocarcinoma
  • Postoperative morbidity

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Gastroenterology

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    Yamamoto, T., Satoi, S., Kawai, M., Motoi, F., Sho, M., Uemura, K. I., Matsumoto, I., Honda, G., Okada, K. I., Akahori, T., Toyama, H., Kurata, M., Yanagimoto, H., Yamaue, H., Unno, M., Kon, M., & Murakami, Y. (2018). Is distal pancreatectomy with en-bloc celiac axis resection effective for patients with locally advanced pancreatic ductal adenocarcinoma? -Multicenter surgical group study. Pancreatology, 18(1), 106-113. https://doi.org/10.1016/j.pan.2017.11.005