Is Ca2+-activated potassium efflux involved in the formation of ischemic brain edema?

Teiji Tominaga, Hiroaki Katagi, S. Tsuyoshi Ohnishi

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

A possible role of Ca2+-activated potassium efflux in brain ischemia was studied using a rat focal cortical infarction model. Three days after ischemic insult, tissue contents of water, sodium, potassium and calcium ions were measured. Charybdotoxin, a specific inhibitor of Ca2+-activated potassium efflux, was found to reduce the formation of ischemic brain edema when a dosage of 0.15 mg/kg was given by i.v. 20-30 min prior to the onset of ischemic insult.

Original languageEnglish
Pages (from-to)376-378
Number of pages3
JournalBrain research
Volume460
Issue number2
DOIs
Publication statusPublished - 1988 Sep 20
Externally publishedYes

Keywords

  • Calcium-activated potassium channel
  • Charybdotoxin
  • Focal ischemia
  • Ischemic brain edema

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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