TY - JOUR
T1 - Irview
T2 - A database and viewer for protein interacting regions
AU - Fujimori, Shigeo
AU - Hirai, Naoya
AU - Masuoka, Kazuyo
AU - Oshikubo, Tomohiro
AU - Yamashita, Tatsuhiro
AU - Washio, Takanori
AU - Saito, Ayumu
AU - Nagasaki, Masao
AU - Miyano, Satoru
AU - Miyamoto-Sato, Etsuko
N1 - Funding Information:
Funding: Grant-in-Aid for Scientific Research on Innovative Areas ‘Integrative Systems Understanding of Cancer for Advanced Diagnosis, Therapy and Prevention (No. 4201)’ (grant number 23134510) of The Ministry of Education, Culture, Sports, Science and Technology, Japan (to S.F.); Female Researcher Science Grant from Shiseido Co., Ltd (to E.M.-S.).
PY - 2012/7
Y1 - 2012/7
N2 - Protein-protein interactions (PPIs) are mediated through specific regions on proteins. Some proteins have two or more protein interacting regions (IRs) and some IRs are competitively used for interactions with different proteins. IRView currently contains data for 3417 IRs in human and mouse proteins. The data were obtained from different sources and combined with annotated region data from InterPro. Information on non-synonymous single nucleotide polymorphism sites and variable regions owing to alternative mRNA splicing is also included. The IRView web interface displays all IR data, including user-uploaded data, on reference sequences so that the positional relationship between IRs can be easily understood. IRView should be useful for analyzing underlying relationships between the proteins behind the PPI networks.
AB - Protein-protein interactions (PPIs) are mediated through specific regions on proteins. Some proteins have two or more protein interacting regions (IRs) and some IRs are competitively used for interactions with different proteins. IRView currently contains data for 3417 IRs in human and mouse proteins. The data were obtained from different sources and combined with annotated region data from InterPro. Information on non-synonymous single nucleotide polymorphism sites and variable regions owing to alternative mRNA splicing is also included. The IRView web interface displays all IR data, including user-uploaded data, on reference sequences so that the positional relationship between IRs can be easily understood. IRView should be useful for analyzing underlying relationships between the proteins behind the PPI networks.
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U2 - 10.1093/bioinformatics/bts289
DO - 10.1093/bioinformatics/bts289
M3 - Article
C2 - 22592381
AN - SCOPUS:84864150517
VL - 28
SP - 1949
EP - 1950
JO - Bioinformatics
JF - Bioinformatics
SN - 1367-4803
IS - 14
M1 - bts289
ER -