Irsogladine is a potent inhibitor of angiogenesis

Yasufumi Sato, Akio Morimoto, Akira Kiue, Kazuki Okamura, Ryoji Hamanaka, Kimitoshi Kohno, Michihiko Kuwano, Toshiie Sakata

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

We describe a novel inhibitor of angiogenesis, Irsogladine, an anti-ulcer drug. Irsogladine inhibited plasminogen activator synthesis of, and tube formation by, human microvascular endothelial cells in type 1 collagen gel treated with an angiogenic growth factor, EGF. Furthermore, Irsogladine administered orally significantly inhibited in vivo angiogenesis in mice. Irsogladine may be useful in the treatment of diseases associated with angiogenesis.

Original languageEnglish
Pages (from-to)155-158
Number of pages4
JournalFEBS Letters
Volume322
Issue number2
DOIs
Publication statusPublished - 1993 May 10
Externally publishedYes

Keywords

  • Angiogenesis
  • Irsogladine
  • Plasminogen activator

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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