TY - CHAP
T1 - Iron in Cancer Progression
T2 - Does BACH1 Promote Metastasis by Altering Iron Homeostasis?
AU - Igarashi, Kazuhiko
AU - Nishizawa, Hironari
AU - Matsumoto, Mitsuyo
N1 - Funding Information:
Acknowledgment We are indebted to stimulating discussion with and contribution from laboratory members. Investigation by the authors have been supported by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (20KK0176 and 18H04021 to KI, 20K16296 and 19K23738 to HN, and 19K07680 and 16K07108 to MM), Grant-in-Aid for Joint Research by Young Researchers from Tohoku University Graduate School of Medicine (to H.N.), Gonryo Medical Foundation (to H.N.), and Takeda Science Foundation (to H.N.).
Publisher Copyright:
© 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.
PY - 2022
Y1 - 2022
N2 - The transcription factor BACH1, which is regulated by direct binding of prosthetic group heme, promotes epithelial-mesenchymal transition (EMT) and drives metastasis of diverse types of cancer cells. De-regulated target genes of BACH1 in cancer cells include those for glycolysis, oxidative phosphorylation, epithelial cell adhesion, and mesodermal cell motility. In addition, the canonical target genes of BACH1 include genes for the regulation of iron homeostasis. Importantly, cancer cells are addicted to iron. We summarize known functions of BACH1 in cancer and discuss how BACH1 may affect iron homeostasis in cancer cells to support their progression by increasing mobile iron within cells. The dependency on BACH1 for cancer progression may also confer upon cancer cells susceptibility to iron-dependent cell death ferroptosis. Finally, we discuss that the human transcription factors provide research opportunities for better understanding of cancer cell properties.
AB - The transcription factor BACH1, which is regulated by direct binding of prosthetic group heme, promotes epithelial-mesenchymal transition (EMT) and drives metastasis of diverse types of cancer cells. De-regulated target genes of BACH1 in cancer cells include those for glycolysis, oxidative phosphorylation, epithelial cell adhesion, and mesodermal cell motility. In addition, the canonical target genes of BACH1 include genes for the regulation of iron homeostasis. Importantly, cancer cells are addicted to iron. We summarize known functions of BACH1 in cancer and discuss how BACH1 may affect iron homeostasis in cancer cells to support their progression by increasing mobile iron within cells. The dependency on BACH1 for cancer progression may also confer upon cancer cells susceptibility to iron-dependent cell death ferroptosis. Finally, we discuss that the human transcription factors provide research opportunities for better understanding of cancer cell properties.
KW - BACH1
KW - Cancer
KW - Epigenetics
KW - Epithelial-Mesenchymal transition
KW - Iron
KW - Metastasis
KW - Transcription factor
UR - http://www.scopus.com/inward/record.url?scp=85140862300&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85140862300&partnerID=8YFLogxK
U2 - 10.1007/978-3-031-07634-3_2
DO - 10.1007/978-3-031-07634-3_2
M3 - Chapter
C2 - 36301491
AN - SCOPUS:85140862300
T3 - Subcellular Biochemistry
SP - 67
EP - 80
BT - Subcellular Biochemistry
PB - Springer Science and Business Media B.V.
ER -
