Iron-catalyzed direct arylation through directed C-H bond activation

Jakob Norinder, Arimasa Matsumoto, Naohiko Yoshikai, Eiichi Nakamura

Research output: Contribution to journalArticlepeer-review

311 Citations (Scopus)

Abstract

An iron-catalyzed C-C bond formation reaction of a nitrogen-containing aromatic compound with an arylzinc reagent takes place at 0 °C in a good to quantitative yield. The reaction involves a C-H bond activation directed by a neighboring nitrogen atom. The important additives in this reaction are 1,10-phenanthroline, tetramethylethylenediamine, and 1,2-dichloro-2-methylpropane, in the absence of which a very low product yield was observed.

Original languageEnglish
Pages (from-to)5858-5859
Number of pages2
JournalJournal of the American Chemical Society
Volume130
Issue number18
DOIs
Publication statusPublished - 2008 May 7
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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