Iron-catalyzed direct arylation of aryl pyridines and imines using oxygen as an oxidant

Naohiko Yoshikai, Arimasa Matsumoto, Jakob Norinder, Eiichi Nakamura

Research output: Contribution to journalArticlepeer-review

60 Citations (Scopus)

Abstract

An iron-catalyzed ortho C-H bond arylation reaction of an aryl pyridine or imine with an arylzinc reagent, which previously required the use of a rather expensive organodichloride as an oxidant, can now be achieved under oxygen atmosphere. By slowly introducing oxygen into the reaction, oxidative cross-coupling of the two reactants took place smoothly to give a biaryl product in moderate to good yield.

Original languageEnglish
Pages (from-to)313-316
Number of pages4
JournalSynlett
Issue number2
DOIs
Publication statusPublished - 2010
Externally publishedYes

Keywords

  • Biaryls
  • C-H bond activation
  • Cross-coupling
  • Iron

ASJC Scopus subject areas

  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Iron-catalyzed direct arylation of aryl pyridines and imines using oxygen as an oxidant'. Together they form a unique fingerprint.

Cite this