Iridoids and sesquiterpenoids with NGF-potentiating activity from the rhizomes and roots of Valeriana fauriei

Yuanqiang Guo; Jing Xu; Yushan Li; Ryuichi Watanabe; Yasukatsu Oshima; Tohru Yamakuni; Yasushi Ohizumi

doi:10.1248/cpb.54.123

Iridoids and sesquiterpenoids with NGF-potentiating activity from the rhizomes and roots of Valeriana fauriei

Yuanqiang Guo, Jing Xu, Yushan Li, Ryuichi Watanabe, Yasukatsu Oshima, Tohru Yamakuni, Yasushi Ohizumi

PHA - Life and Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

A new iridoid glycoside, 10-isovaleryl kanokoside C (1), and a new sesquiterpene (2) together with two known compounds (3, 4) were isolated from the rhizomes and roots of Valeriana fauriei. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 2 and 4 showed enhancing activity of nerve growth factor (NGF)-induced neurite outgrowth in PC 12D cells.

Original language	English
Pages (from-to)	123-125
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	54
Issue number	1
DOIs	https://doi.org/10.1248/cpb.54.123
Publication status	Published - 2006 Jan

Keywords

Iridoid glycoside
Nerve growth factor (NGF)-potentiating activity
Sesquiterpenoid
Valeriana fauriei

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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Iridoids and sesquiterpenoids with NGF-potentiating activity from the rhizomes and roots of Valeriana fauriei. / Guo, Yuanqiang; Xu, Jing; Li, Yushan; Watanabe, Ryuichi; Oshima, Yasukatsu; Yamakuni, Tohru; Ohizumi, Yasushi.

In: Chemical and Pharmaceutical Bulletin, Vol. 54, No. 1, 01.2006, p. 123-125.

Research output: Contribution to journal › Article › peer-review

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AU - Watanabe, Ryuichi

AU - Oshima, Yasukatsu

AU - Yamakuni, Tohru

AU - Ohizumi, Yasushi

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Iridoids and sesquiterpenoids with NGF-potentiating activity from the rhizomes and roots of Valeriana fauriei

Abstract

Keywords

ASJC Scopus subject areas

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