Iridoids and sesquiterpenoids with NGF-potentiating activity from the rhizomes and roots of Valeriana fauriei

Yuanqiang Guo, Jing Xu, Yushan Li, Ryuichi Watanabe, Yasukatsu Oshima, Tohru Yamakuni, Yasushi Ohizumi

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

A new iridoid glycoside, 10-isovaleryl kanokoside C (1), and a new sesquiterpene (2) together with two known compounds (3, 4) were isolated from the rhizomes and roots of Valeriana fauriei. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 2 and 4 showed enhancing activity of nerve growth factor (NGF)-induced neurite outgrowth in PC 12D cells.

Original languageEnglish
Pages (from-to)123-125
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume54
Issue number1
DOIs
Publication statusPublished - 2006 Jan

Keywords

  • Iridoid glycoside
  • Nerve growth factor (NGF)-potentiating activity
  • Sesquiterpenoid
  • Valeriana fauriei

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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