Ion permeation and selectivity of squid axon sodium channels modified by tetramethrin

Daisuke Yamamoto, Jay Z. Yeh, Toshio Narahashi

    Research output: Contribution to journalArticlepeer-review

    14 Citations (Scopus)

    Abstract

    The pyrethroid tetramethrin greatly prolongs the sodium current during step depolarization and the sodium tail current associated with step repolarization of the squid axon membrane. Non-linear current-voltage relationships for the sodium tail current were analyzed to assess the open sodium channel properties which included the permeation of various cations, calcium block and cation selectivity. Tetramethrin had no effect on any of these properties. It was concluded that tetramethrin modifies the sodium channel gating machinery without affecting the pore properties.

    Original languageEnglish
    Pages (from-to)193-197
    Number of pages5
    JournalBrain research
    Volume372
    Issue number1
    DOIs
    Publication statusPublished - 1986 Apr 30

    Keywords

    • ion permeation
    • ion selectivity
    • pyrethroid
    • sodium channel
    • tetramethrin

    ASJC Scopus subject areas

    • Neuroscience(all)
    • Molecular Biology
    • Clinical Neurology
    • Developmental Biology

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