Ion conducting polymer microelectrodes for interfacing with neural networks

Tobias Nyberg, Akiyoshi Shimada, Keiichi Torimitsu

Research output: Contribution to journalArticlepeer-review

88 Citations (Scopus)

Abstract

We have examined the stimulation and recording properties of conjugated polymer microelectrode arrays as interfaces with neural networks of dissociated cortical cells. In particular the stimulation properties were investigated as a means of supplying a neural network with information. The stimulation efficiency at low stimulation voltages was evaluated and referenced to bare indium tin oxide (ITO) electrodes. The polymer electrodes were electrochemically polymerized from a blend of poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT-PSS) and ethylenedioxythiophene (EDOT) onto ITO microelectrodes. Dissociated cortical cells were then plated on the electrodes and cultivated to form neural networks. Polymer electrode stimulation evoked a much greater response from the network than stimulation from ITO electrodes. Neural interfaces using polymer electrodes could be maintained for several months.

Original languageEnglish
Pages (from-to)16-25
Number of pages10
JournalJournal of Neuroscience Methods
Volume160
Issue number1
DOIs
Publication statusPublished - 2007 Feb 15
Externally publishedYes

Keywords

  • Conducting polymer
  • Electrical stimulation
  • MEA
  • Microelectrode array
  • Neural network
  • PEDOT-PSS

ASJC Scopus subject areas

  • Neuroscience(all)

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