Involvement of tryptase-related cellular protease(s) in human immunodeficiency virus type 1 infection

Toshio Hattori, Atsushi Koito, Kiyoshi Takatsuki, Hiroshi Kido, Nobuhiko Katunuma

Research output: Contribution to journalArticlepeer-review

128 Citations (Scopus)

Abstract

Trypstatin, a new cellular Kunitz-type protease inhibitor purified from rat mast cells, inhibited syncytium formation in human immunodeficiency virus type 1 (HIV-1)-infected CCRF-CEM and uninfected Molt-4 clone 8 at a concentration of 1 μM. Anti-rat tongue mast cell tryptase antibodies reacted with Molt-4 clone 8 cells, as determined by Western blot and by immunofluorescence. In addition, the antibody inhibited syncytium formation. These findings along with homologous sequences with trypstatin and a neutralizing epitope of gp120 of HIV-1 suggest that a tryptase-like cellular enzyme(s) is involved in HIV-1 infection.

Original languageEnglish
Pages (from-to)48-52
Number of pages5
JournalFEBS Letters
Volume248
Issue number1-2
DOIs
Publication statusPublished - 1989 May 8

Keywords

  • HIV-1
  • Neutralization
  • Trypstatin
  • Tryptase

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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