Involvement of the brain type of ryanodine receptor in T-cell proliferation

Yasuhiro Hakamata, Seiichiro Nishimura, Junichi Nakai, Yasuyo Nakashima, Toru Kita, Keiji Imoto

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Cloning and sequence analysis of cDNA showed that the brain type of ryanodine receptor (RYR) is expressed in human Jurkat T-lymphocyte cells. Fura-2 measurements revealed that the RYR in T-cells functions as a ryanodine-sensitive, caffeine-insensitive Ca2+ release channel. Furthermore, ryanodine stimulated proliferation and altered the growth pattern of cultured human T-cells when added together with FK506.

Original languageEnglish
Pages (from-to)206-210
Number of pages5
JournalFEBS Letters
Volume352
Issue number2
DOIs
Publication statusPublished - 1994 Sep 26
Externally publishedYes

Keywords

  • Calcium release
  • Cell proliferation
  • FK506
  • Jurkat T-lymphocyte
  • Ryanodine receptor
  • cDNA cloning

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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  • Cite this

    Hakamata, Y., Nishimura, S., Nakai, J., Nakashima, Y., Kita, T., & Imoto, K. (1994). Involvement of the brain type of ryanodine receptor in T-cell proliferation. FEBS Letters, 352(2), 206-210. https://doi.org/10.1016/0014-5793(94)00955-4