Involvement of spot 35 protein, a cerebellar protein, in modulation of Purkinje cell activity of the rat cerebellum

Shoji Maruyama, Ge Zhang, Yoshimatsu Tamura, Tohru Yamakuni, Yasuo Takahashi

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Spot 35 protein, applied iontophoretically, produced inhibition of spontaneous Purkinje cell activity in most cells and augmented the NE- or 5-HT-induced inhibition of spontaneous discharges whereas it hardly affected the inhibitory response of Purkinje cells to GABA, taurine, and β-alanine, and the excitatory response to glutamate. It is suggested that spot 35 protein may be involved in normal physiological operation of the cerebellum through modulation of the NE or 5-HT system.

Original languageEnglish
Pages (from-to)309-313
Number of pages5
JournalEuropean Journal of Pharmacology
Volume108
Issue number3
DOIs
Publication statusPublished - 1985 Feb 5

Keywords

  • Amino acids
  • Cerebellum
  • Norepinephrine
  • Serotonin
  • Spot 35 protein
  • cGMP

ASJC Scopus subject areas

  • Pharmacology

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