Involvement of selenoprotein P in the regulation of redox balance and myofibroblast viability in idiopathic pulmonary fibrosis

Yukihito Kabuyama, Kengo Oshima, Takuya Kitamura, Miwako Homma, Junko Yamaki, Mitsuru Munakata, Yoshimi Homma

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Idiopathic pulmonary fibrosis (IPF), a chronic progressive lung disease of unknown etiology, is characterized by the expansion of myofibroblasts and abnormal deposition of extracellular matrix in the lung parenchyma. To elucidate the molecular mechanisms that lead to IPF, we analyzed myofibroblasts established from patients with IPF by oligonucleotide microarrays. Gene expression profiles clearly suggested that lipid peroxidation is enhanced in myofibroblasts, which was confirmed by measuring cellular lipid hydroperoxides. One of the most highly up-regulated proteins in myofibroblasts was selenoprotein P, an antioxidant protein not previously associated with IPF. Subsequent analysis demonstrated that selenoprotein P reduces lipid hydroperoxides and maintains the viability of myofibroblasts. Thus, our results reveal a novel pathophysiologic function of myofibroblasts as a generator of lipid hydroperoxides, and a self-defense mechanism against self-generated oxidative stress.

Original languageEnglish
Pages (from-to)1235-1244
Number of pages10
JournalGenes to Cells
Volume12
Issue number11
DOIs
Publication statusPublished - 2007 Nov

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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