TY - JOUR
T1 - Involvement of renal γ-glutamyltranspeptidase in differences in the renal uptake of mercuric mercury by male and female mice of various strains and ages
AU - Tanaka-Kagawa, T.
AU - Miura, N.
AU - Kobayashi, K.
AU - Imura, N.
AU - Naganuma, A.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1999
Y1 - 1999
N2 - Involvement of renal γ-glutamyltranspeptidase (γ-GTP) in differences in the renal uptake of Hg2+ by male and female mice of various ages was examined using five strains of mice, namely, BALB/cA, C57BL/6N, CBA/JN, C3H/HeN and ICR. We observed strain-related and gender-related differences in the renal accumulation of Hg2+ 30 min after the administration of mercuric chloride (1 μmol/kg, s.c.). Renal γ-GTP activity also varied among the tested strains, and the activity in males was about twice that in females. A significant correlation was recognized between renal γ-GTP activity and the renal accumulation of Hg2+. Both renal uptake of Hg2+ and renal γ-GTP activity increased gradually with age in male ICR mice from 2 to 8 weeks after birth but remained relatively constant in ICR females. Significant gender-related differences in both renal accumulation of Hg2+ and γ-GTP activity were observed 4 weeks after birth and thereafter. Castration of male ICR mice decreased both renal accumulation of Hg2+ and γ-GTP activity to the levels in females. Injection of testosterone increased both renal accumulation of Hg2+ and γ-GTP activity in castrated male mice and in normal female mice to the levels in control male mice. These results suggest that strain-related, gender-related and age-related differences in the renal accumulation of Hg2+ in mice might be due to differences in renal γ-GTP activity and, furthermore, that renal γ-GTP activity might be controlled, at least to some extent, by testosterone.
AB - Involvement of renal γ-glutamyltranspeptidase (γ-GTP) in differences in the renal uptake of Hg2+ by male and female mice of various ages was examined using five strains of mice, namely, BALB/cA, C57BL/6N, CBA/JN, C3H/HeN and ICR. We observed strain-related and gender-related differences in the renal accumulation of Hg2+ 30 min after the administration of mercuric chloride (1 μmol/kg, s.c.). Renal γ-GTP activity also varied among the tested strains, and the activity in males was about twice that in females. A significant correlation was recognized between renal γ-GTP activity and the renal accumulation of Hg2+. Both renal uptake of Hg2+ and renal γ-GTP activity increased gradually with age in male ICR mice from 2 to 8 weeks after birth but remained relatively constant in ICR females. Significant gender-related differences in both renal accumulation of Hg2+ and γ-GTP activity were observed 4 weeks after birth and thereafter. Castration of male ICR mice decreased both renal accumulation of Hg2+ and γ-GTP activity to the levels in females. Injection of testosterone increased both renal accumulation of Hg2+ and γ-GTP activity in castrated male mice and in normal female mice to the levels in control male mice. These results suggest that strain-related, gender-related and age-related differences in the renal accumulation of Hg2+ in mice might be due to differences in renal γ-GTP activity and, furthermore, that renal γ-GTP activity might be controlled, at least to some extent, by testosterone.
KW - Gender-related difference
KW - Mercuric mercury
KW - Mouse
KW - Renal uptake
KW - Strain- related difference
KW - γ-glutamyltranspeptidase
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U2 - 10.1248/jhs.45.59
DO - 10.1248/jhs.45.59
M3 - Article
AN - SCOPUS:0033037314
VL - 45
SP - 59
EP - 62
JO - Japanese Journal of Toxicology and Environmental Health
JF - Japanese Journal of Toxicology and Environmental Health
SN - 0013-273X
IS - 2
ER -