TY - JOUR
T1 - Involvement of cardiac metallothionein in prevention of adriamycin induced lipid peroxidation in the heart
AU - Masahiko Satoh, Satoh
AU - Akira Naganuma, Naganuma
AU - Nobumasa Imura, Imura
N1 - Funding Information:
This researchw as supportedb y a Grant-in-Aid for Special Project Research, Cancer-Biosciencefr,o m the Ministry of Education, Science and Culture, Japan (No. 61210030).
PY - 1988/12/30
Y1 - 1988/12/30
N2 - The effect of pretreatment of mice with heavy metals: Zn, Cu, Bi, Co, Cd or Hg, against lethal and cardiac toxicity of adriamycin (ADR) was investigated. The lethal toxicity of ADR was significantly reduced by pre-administration of these metals except for Cu. The levels of both malondialdehyde and conjugated dienes, determined as indicators of lipid peroxidation in the heart, markedly increased with ADR administration, but the increases were significantly prevented by the pre-administration of Zn, Bi or Cd. The survival rate of mice after ADR injection was significantly correlated with metallothionein (MT) levels in the hearts which was increased by the injection of each metal, but was not correlated with those in the liver and kidneys. A significant negative correlation between the cardiac MT concentrations and the levels of lipid peroxidation in the hearts was also observed. These results suggest that increased MT synthesis in the heart may be involved in the protective effect of the heavy metals tested against the lethal and cardiac toxicities of ADR.
AB - The effect of pretreatment of mice with heavy metals: Zn, Cu, Bi, Co, Cd or Hg, against lethal and cardiac toxicity of adriamycin (ADR) was investigated. The lethal toxicity of ADR was significantly reduced by pre-administration of these metals except for Cu. The levels of both malondialdehyde and conjugated dienes, determined as indicators of lipid peroxidation in the heart, markedly increased with ADR administration, but the increases were significantly prevented by the pre-administration of Zn, Bi or Cd. The survival rate of mice after ADR injection was significantly correlated with metallothionein (MT) levels in the hearts which was increased by the injection of each metal, but was not correlated with those in the liver and kidneys. A significant negative correlation between the cardiac MT concentrations and the levels of lipid peroxidation in the hearts was also observed. These results suggest that increased MT synthesis in the heart may be involved in the protective effect of the heavy metals tested against the lethal and cardiac toxicities of ADR.
KW - Adriamycin
KW - Bismuth
KW - Cadmium
KW - Lipid peroxidation
KW - Metallothionein
KW - Zinc
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U2 - 10.1016/0300-483X(88)90216-8
DO - 10.1016/0300-483X(88)90216-8
M3 - Article
C2 - 3212785
AN - SCOPUS:0024236167
VL - 53
SP - 231
EP - 237
JO - Toxicology
JF - Toxicology
SN - 0300-483X
IS - 2-3
ER -