Involvement of cardiac metallothionein in prevention of adriamycin induced lipid peroxidation in the heart

Satoh Masahiko Satoh, Naganuma Akira Naganuma, Imura Nobumasa Imura

Research output: Contribution to journalArticlepeer-review

63 Citations (Scopus)

Abstract

The effect of pretreatment of mice with heavy metals: Zn, Cu, Bi, Co, Cd or Hg, against lethal and cardiac toxicity of adriamycin (ADR) was investigated. The lethal toxicity of ADR was significantly reduced by pre-administration of these metals except for Cu. The levels of both malondialdehyde and conjugated dienes, determined as indicators of lipid peroxidation in the heart, markedly increased with ADR administration, but the increases were significantly prevented by the pre-administration of Zn, Bi or Cd. The survival rate of mice after ADR injection was significantly correlated with metallothionein (MT) levels in the hearts which was increased by the injection of each metal, but was not correlated with those in the liver and kidneys. A significant negative correlation between the cardiac MT concentrations and the levels of lipid peroxidation in the hearts was also observed. These results suggest that increased MT synthesis in the heart may be involved in the protective effect of the heavy metals tested against the lethal and cardiac toxicities of ADR.

Original languageEnglish
Pages (from-to)231-237
Number of pages7
JournalToxicology
Volume53
Issue number2-3
DOIs
Publication statusPublished - 1988 Dec 30

Keywords

  • Adriamycin
  • Bismuth
  • Cadmium
  • Lipid peroxidation
  • Metallothionein
  • Zinc

ASJC Scopus subject areas

  • Toxicology

Fingerprint Dive into the research topics of 'Involvement of cardiac metallothionein in prevention of adriamycin induced lipid peroxidation in the heart'. Together they form a unique fingerprint.

Cite this