TY - JOUR
T1 - Involvement of a novel ADP-ribosylation factor GTPase-activating protein, SMAP, in membrane trafficking
T2 - Implications in cancer cell biology
AU - Tanabe, Kenji
AU - Kon, Shunsuke
AU - Natsume, Waka
AU - Torii, Tetsuo
AU - Watanabe, Toshio
AU - Satake, Masanobu
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2006/9
Y1 - 2006/9
N2 - The endocytosis of cell membrane proteins is initiated by the binding of activated Arf6, a member of Ras-related GTPases, to the PM. A GAP specific for Arf6 triggers the budding of endocytotic vesicles from the PM by inactivating GTP-bound Arf6. We recently identified the SMAP gene that encodes an ArfGAP and is involved in the endocytosis of TfnR and possibly E-cadherin. In this review, we summarize the process of intracellular membrane trafficking, highlighting the roles played by the SMAP gene. Progression of cancer to malignancy occurs in parallel with the disappearance of E-cadherin, a central component of the adherens junction in epithelial cells. Therefore, elucidation of the molecular mechanism of E-cadherin endocytosis should be one of the key elements in tumor cell biology.
AB - The endocytosis of cell membrane proteins is initiated by the binding of activated Arf6, a member of Ras-related GTPases, to the PM. A GAP specific for Arf6 triggers the budding of endocytotic vesicles from the PM by inactivating GTP-bound Arf6. We recently identified the SMAP gene that encodes an ArfGAP and is involved in the endocytosis of TfnR and possibly E-cadherin. In this review, we summarize the process of intracellular membrane trafficking, highlighting the roles played by the SMAP gene. Progression of cancer to malignancy occurs in parallel with the disappearance of E-cadherin, a central component of the adherens junction in epithelial cells. Therefore, elucidation of the molecular mechanism of E-cadherin endocytosis should be one of the key elements in tumor cell biology.
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U2 - 10.1111/j.1349-7006.2006.00251.x
DO - 10.1111/j.1349-7006.2006.00251.x
M3 - Review article
C2 - 16805823
AN - SCOPUS:33746591487
VL - 97
SP - 801
EP - 806
JO - Cancer Science
JF - Cancer Science
SN - 1347-9032
IS - 9
ER -