Involvement of a novel ADP-ribosylation factor GTPase-activating protein, SMAP, in membrane trafficking: Implications in cancer cell biology

Kenji Tanabe, Shunsuke Kon, Waka Natsume, Tetsuo Torii, Toshio Watanabe, Masanobu Satake

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

The endocytosis of cell membrane proteins is initiated by the binding of activated Arf6, a member of Ras-related GTPases, to the PM. A GAP specific for Arf6 triggers the budding of endocytotic vesicles from the PM by inactivating GTP-bound Arf6. We recently identified the SMAP gene that encodes an ArfGAP and is involved in the endocytosis of TfnR and possibly E-cadherin. In this review, we summarize the process of intracellular membrane trafficking, highlighting the roles played by the SMAP gene. Progression of cancer to malignancy occurs in parallel with the disappearance of E-cadherin, a central component of the adherens junction in epithelial cells. Therefore, elucidation of the molecular mechanism of E-cadherin endocytosis should be one of the key elements in tumor cell biology.

Original languageEnglish
Pages (from-to)801-806
Number of pages6
JournalCancer science
Volume97
Issue number9
DOIs
Publication statusPublished - 2006 Sep 1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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