In‐vitro Evidence for Carrier‐mediated Uptake of Acidic Drugs by Isolated Bovine Brain Capillaries

TETSUYA TERASAKI, YOUNG SOOK KANG, TOSHIMASA OHNISHI, AKIRA TSUJI

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Abstract— [3H]Acetic acid was taken up into the isolated brain capillaries in a temperature and concentration dependent manner. The initial uptake rates were pH dependent over the range 5.0–7.4. An increase of the uptake rate with decrease in medium pH was not seen in the presence of unlabelled acetic acid (10 mM). The uptake of [3H]acetic acid was significantly reduced in the presence of several drugs having a monocarboxylic group. The initial uptake of [14C]salicylic acid was also pH dependent and was inhibited by acetic acid and acidic drugs. A mutually competitive inhibition was observed for the uptake of acetic acid and salicylic acid. The present study demonstrates that acidic drugs having a monocarboxylic group are transported by a common carrier‐mediated system into the brain capillaries. 1991 Royal Pharmaceutical Society of Great Britain

Original languageEnglish
Pages (from-to)172-176
Number of pages5
JournalJournal of Pharmacy and Pharmacology
Volume43
Issue number3
DOIs
Publication statusPublished - 1991 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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