Investigation of the clinicopathological features of squamous cell carcinoma of the vulva: a retrospective survey of the Tohoku Gynecologic Cancer Unit

Masayuki Futagami, Yoshihito Yokoyama, Kaori Iino, Masahiko Aoki, Tadahiro Shoji, Toru Sugiyama, Hisanori Ariga, Hideki Tokunaga, Tadao Takano, Yoh Watanabe, Nobuo Yaegashi, Keiichi Jingu, Naoki Sato, Yukihiro Terada, Akira Anbai, Tsuyoshi Ohta, Hirohisa Kurachi, Yuuki Kuroda, Hiroshi Nishiyama, Keiya FujimoriTakafumi Watanabe, Hisashi Sato, Toru Tase, Hitoshi Wada, Hideki Mizunuma

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: This multi-institutional study was conducted to clarify the clinicopathological features of squamous cell carcinomas of the vulva. Methods: The medical records of vulvar cancer patients treated between 2002 and 2012 were retrospectively reviewed following approval by the Institutional Review Board of each institution. Results: One hundred and eleven patients with vulvar malignancies were included. Of these, 63 patients had squamous cell carcinoma (57 %). Initial treatment was surgery, radiation therapy (RT), and concurrent chemoradiotherapy (CCRT) in 34 (54 %), 15 (24 %), and 11 (17 %) patients, respectively. Nineteen, 11, 26, and 7 patients had stage I, II, III, and IV disease, respectively. Of the 34 patients who had surgical treatment, 50 % had stage I disease, while 74 % of those who received CCRT had stage III or IV disease. Complete response (CR) rates for the surgery, RT, and CCRT groups were 73, 60, and 64 %, respectively. The 5-year survival rates for stage I/II and III/IV disease were 64 and 39 %, respectively (P = 0.019). The 5-year survival rates for the surgery, RT, and CCRT groups were 53, 38, and 50 %, respectively, and the prognosis of patients treated with surgery or CCRT was significantly better than that of patients who received RT (P < 0.05). In multivariate analysis, clinical response to initial treatment was an independent prognostic factor (P < 0.001). Conclusions: Although many patients had advanced-stage disease in the CCRT group, the therapeutic outcome for the surgery and CCRT groups was similar. Thus, CCRT may be a promising treatment for squamous cell carcinoma of the vulva.

Original languageEnglish
Pages (from-to)1005-1011
Number of pages7
JournalInternational Journal of Clinical Oncology
Volume20
Issue number5
DOIs
Publication statusPublished - 2015 Oct 3

Keywords

  • CCRT
  • Prognosis
  • Squamous cell carcinoma of the vulva
  • Surgery

ASJC Scopus subject areas

  • Surgery
  • Hematology
  • Oncology

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    Futagami, M., Yokoyama, Y., Iino, K., Aoki, M., Shoji, T., Sugiyama, T., Ariga, H., Tokunaga, H., Takano, T., Watanabe, Y., Yaegashi, N., Jingu, K., Sato, N., Terada, Y., Anbai, A., Ohta, T., Kurachi, H., Kuroda, Y., Nishiyama, H., ... Mizunuma, H. (2015). Investigation of the clinicopathological features of squamous cell carcinoma of the vulva: a retrospective survey of the Tohoku Gynecologic Cancer Unit. International Journal of Clinical Oncology, 20(5), 1005-1011. https://doi.org/10.1007/s10147-015-0803-x