TY - JOUR
T1 - Investigation of the clinicopathological features of squamous cell carcinoma of the vulva
T2 - a retrospective survey of the Tohoku Gynecologic Cancer Unit
AU - Futagami, Masayuki
AU - Yokoyama, Yoshihito
AU - Iino, Kaori
AU - Aoki, Masahiko
AU - Shoji, Tadahiro
AU - Sugiyama, Toru
AU - Ariga, Hisanori
AU - Tokunaga, Hideki
AU - Takano, Tadao
AU - Watanabe, Yoh
AU - Yaegashi, Nobuo
AU - Jingu, Keiichi
AU - Sato, Naoki
AU - Terada, Yukihiro
AU - Anbai, Akira
AU - Ohta, Tsuyoshi
AU - Kurachi, Hirohisa
AU - Kuroda, Yuuki
AU - Nishiyama, Hiroshi
AU - Fujimori, Keiya
AU - Watanabe, Takafumi
AU - Sato, Hisashi
AU - Tase, Toru
AU - Wada, Hitoshi
AU - Mizunuma, Hideki
N1 - Publisher Copyright:
© 2015, Japan Society of Clinical Oncology.
PY - 2015/10/3
Y1 - 2015/10/3
N2 - Background: This multi-institutional study was conducted to clarify the clinicopathological features of squamous cell carcinomas of the vulva. Methods: The medical records of vulvar cancer patients treated between 2002 and 2012 were retrospectively reviewed following approval by the Institutional Review Board of each institution. Results: One hundred and eleven patients with vulvar malignancies were included. Of these, 63 patients had squamous cell carcinoma (57 %). Initial treatment was surgery, radiation therapy (RT), and concurrent chemoradiotherapy (CCRT) in 34 (54 %), 15 (24 %), and 11 (17 %) patients, respectively. Nineteen, 11, 26, and 7 patients had stage I, II, III, and IV disease, respectively. Of the 34 patients who had surgical treatment, 50 % had stage I disease, while 74 % of those who received CCRT had stage III or IV disease. Complete response (CR) rates for the surgery, RT, and CCRT groups were 73, 60, and 64 %, respectively. The 5-year survival rates for stage I/II and III/IV disease were 64 and 39 %, respectively (P = 0.019). The 5-year survival rates for the surgery, RT, and CCRT groups were 53, 38, and 50 %, respectively, and the prognosis of patients treated with surgery or CCRT was significantly better than that of patients who received RT (P < 0.05). In multivariate analysis, clinical response to initial treatment was an independent prognostic factor (P < 0.001). Conclusions: Although many patients had advanced-stage disease in the CCRT group, the therapeutic outcome for the surgery and CCRT groups was similar. Thus, CCRT may be a promising treatment for squamous cell carcinoma of the vulva.
AB - Background: This multi-institutional study was conducted to clarify the clinicopathological features of squamous cell carcinomas of the vulva. Methods: The medical records of vulvar cancer patients treated between 2002 and 2012 were retrospectively reviewed following approval by the Institutional Review Board of each institution. Results: One hundred and eleven patients with vulvar malignancies were included. Of these, 63 patients had squamous cell carcinoma (57 %). Initial treatment was surgery, radiation therapy (RT), and concurrent chemoradiotherapy (CCRT) in 34 (54 %), 15 (24 %), and 11 (17 %) patients, respectively. Nineteen, 11, 26, and 7 patients had stage I, II, III, and IV disease, respectively. Of the 34 patients who had surgical treatment, 50 % had stage I disease, while 74 % of those who received CCRT had stage III or IV disease. Complete response (CR) rates for the surgery, RT, and CCRT groups were 73, 60, and 64 %, respectively. The 5-year survival rates for stage I/II and III/IV disease were 64 and 39 %, respectively (P = 0.019). The 5-year survival rates for the surgery, RT, and CCRT groups were 53, 38, and 50 %, respectively, and the prognosis of patients treated with surgery or CCRT was significantly better than that of patients who received RT (P < 0.05). In multivariate analysis, clinical response to initial treatment was an independent prognostic factor (P < 0.001). Conclusions: Although many patients had advanced-stage disease in the CCRT group, the therapeutic outcome for the surgery and CCRT groups was similar. Thus, CCRT may be a promising treatment for squamous cell carcinoma of the vulva.
KW - CCRT
KW - Prognosis
KW - Squamous cell carcinoma of the vulva
KW - Surgery
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U2 - 10.1007/s10147-015-0803-x
DO - 10.1007/s10147-015-0803-x
M3 - Article
C2 - 25708593
AN - SCOPUS:84942981329
VL - 20
SP - 1005
EP - 1011
JO - International Journal of Clinical Oncology
JF - International Journal of Clinical Oncology
SN - 1341-9625
IS - 5
ER -