Investigation of intracellular factors involved in methylmercury toxicity

Akira Naganuma, Takemitsu Furuchi, Nobuhiko Miura, Gi Wook Hwang, Shusuke Kuge

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Methylmercury is a known pollutant that causes severe central nervous system disorders. It is capable of passing through the blood-brain barrier and accumulates in cerebral cells. However, little is known regarding the mechanism of its toxicity at the molecular level. Using yeast cells, we searched for the genes involved in the expression of methylmercury toxicity, and found that genes encoding L-glutamine • D-fructose-6-phosphate amidotransferase (GFAT) and ubiquitin transferase (Ubc3) confer methylmercury resistance on the cells. It has also been shown that GFAT is the target molecule of methylmercury in yeast cells. These findings provide important clues about the mechanism underlying methylmercury toxicity in mammals.

Original languageEnglish
Pages (from-to)65-70
Number of pages6
JournalTohoku Journal of Experimental Medicine
Volume196
Issue number2
DOIs
Publication statusPublished - 2002

Keywords

  • Glucosamine-6-phosphate
  • Methyl-mercury
  • Resistance
  • Ubiquitin
  • Yeast

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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