TY - JOUR
T1 - Investigation of characteristic hemodynamic parameters indicating thinning and thickening sites of cerebral aneurysms
AU - Suzuki, Daichi
AU - Funamoto, Kenichi
AU - Sugiyama, Shinichiro
AU - Nakayama, Toshio
AU - Hayase, Toshiyuki
AU - Tominaga, Teiji
N1 - Publisher Copyright:
© 2015 The Japan Society of Mechanical Engineers.
PY - 2015
Y1 - 2015
N2 - Cellular and animal experiments and computational fluid dynamics (CFD) have revealed that mechanisms of the initiation, growth and rupture of a cerebral aneurysm are related to hemodynamics. By direct observation of a cerebral aneurysm during craniotomy, thinning or thickening sites can be found on the aneurysmal wall. The thinning site of a cerebral aneurysm is considered to be at high risk of rupture. In addition, the thickening site of a cerebral aneurysm is not necessarily in a stable state since arteriosclerosis may have occurred. Hence, information on wall conditions, i.e., thinning and thickening, of a cerebral aneurysm is beneficial for clinical diagnosis and treatment. In this study, a hemodynamic parameter to effectively estimate the thinness or thickness of cerebral aneurysmal walls was investigated. CFD of hemodynamics in cerebral aneurysms developed at the anterior communicating artery (ACoA), a common site of cerebral aneurysms, was performed, and characteristic distributions of hemodynamic parameters were investigated by comparing the computational results with clinical images. As a result, a high value of the time-averaged wall shear stress (TAWSS) was found to be present at thinning sites, while a low TAWSS and a high relative residence time (RRT) of an indicator of blood retention were observed at thickening sites. Thinning and thickening sites each have their own characteristics distribution of hemodynamic parameters.
AB - Cellular and animal experiments and computational fluid dynamics (CFD) have revealed that mechanisms of the initiation, growth and rupture of a cerebral aneurysm are related to hemodynamics. By direct observation of a cerebral aneurysm during craniotomy, thinning or thickening sites can be found on the aneurysmal wall. The thinning site of a cerebral aneurysm is considered to be at high risk of rupture. In addition, the thickening site of a cerebral aneurysm is not necessarily in a stable state since arteriosclerosis may have occurred. Hence, information on wall conditions, i.e., thinning and thickening, of a cerebral aneurysm is beneficial for clinical diagnosis and treatment. In this study, a hemodynamic parameter to effectively estimate the thinness or thickness of cerebral aneurysmal walls was investigated. CFD of hemodynamics in cerebral aneurysms developed at the anterior communicating artery (ACoA), a common site of cerebral aneurysms, was performed, and characteristic distributions of hemodynamic parameters were investigated by comparing the computational results with clinical images. As a result, a high value of the time-averaged wall shear stress (TAWSS) was found to be present at thinning sites, while a low TAWSS and a high relative residence time (RRT) of an indicator of blood retention were observed at thickening sites. Thinning and thickening sites each have their own characteristics distribution of hemodynamic parameters.
KW - Cerebral aneurysm
KW - Computational fluid dynamics
KW - Hemodynamics
KW - Wall conditions
KW - Wall shear stress
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U2 - 10.1299/jbse.14-00265
DO - 10.1299/jbse.14-00265
M3 - Article
AN - SCOPUS:84929467837
VL - 10
SP - 1
EP - 10
JO - Journal of Biomechanical Science and Engineering
JF - Journal of Biomechanical Science and Engineering
SN - 1880-9863
IS - 1
ER -