Investigation into mechanism of protein resistance based on hydration states in polymer chains

Toshinori Morisaku, Tomohiro Konno, Madoka Takai, Kazuhiko Ishihara

Research output: Contribution to conferencePaperpeer-review

Abstract

This research object is an understanding of hydration states in polymer chains for inducing the protein resistance. We analyzed hydration states of 2-methacryloyloxyethyl phosphorylcholine polymer (poly(MPC)) with the same structure as phospholipid headgroups in cell membranes. The poly(MPC) hydrogels were prepared to have EWC ranging from 86 to 92 wt % and hydration states in the hydrogels are measured by DSC. Results are compared with those in the hydrogels composed of non-biomimetic reference methoxy oligo(ethylene glycol) methacrylate polymer (poly(MeOEGMA-n) (n = 4 and 8)). For the hydrogels with similar EWC, the poly(MPC) hydrogels exhibit 1.2-2.1 times higher fractions of nonfreezing water than the poly(MeOEGMA-n) hydrogels. Also, the number of nonfreezing water per the phosphorylcholine group and the ethylene glycol repeat unit is estimated as 20-26 and 2.8-4.1, respectively.

Original languageEnglish
Pages5416-5417
Number of pages2
Publication statusPublished - 2006 Dec 1
Externally publishedYes
Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
Duration: 2006 Sep 202006 Sep 22

Other

Other55th Society of Polymer Science Japan Symposium on Macromolecules
Country/TerritoryJapan
CityToyama
Period06/9/2006/9/22

Keywords

  • Hydration states
  • MPC polymer
  • Non-freezing water
  • Phosphorylcholine group
  • Protein resistance

ASJC Scopus subject areas

  • Engineering(all)

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