TY - GEN
T1 - Investigating the beat by beat phase synchronization between maternal and fetal heart rates
AU - Wang, Qianqian
AU - Khandoker, Ahsan H.
AU - Marzbanrad, Faezeh
AU - Funamoto, Kiyoe
AU - Sugibayashi, Rika
AU - Endo, Miyuki
AU - Kimura, Yoshitaka
AU - Palaniswami, Marimuthu
PY - 2013
Y1 - 2013
N2 - The development of the fetal cardiovascular system plays a crucial role in fetal health. The evolution of the relationship between fetal and maternal cardiac systems during fetal maturation is a characterizing feature for fetal cardiac development. This paper aims to evaluate this relationship by investigating the beat-to-beat synchronization between fetal and maternal heart rates and its variation at different stages of pregnancy. Synchronization epochs and phase locking patterns are analyzed at certain synchronization ratios (SRs) for three gestational age groups (16-26 weeks, 27-33 weeks, 34-40 weeks). Results show that the normalized synchronization epoch is significantly different for three age groups with the p-value of 6.72 10-6 and 2.89 10-4 at SR of 1-2 and 4-5 respectively. The variance of phase locking also shows significant difference for three groups with the p-value less than 10-7 at four SRs. Results also suggest that synchronization may be the force behind the increase in the maternal heart rate to maintain the fetal development and provide supplies for the fetus. Overall, the findings propose new clinical markers for evaluating the antenatal development.
AB - The development of the fetal cardiovascular system plays a crucial role in fetal health. The evolution of the relationship between fetal and maternal cardiac systems during fetal maturation is a characterizing feature for fetal cardiac development. This paper aims to evaluate this relationship by investigating the beat-to-beat synchronization between fetal and maternal heart rates and its variation at different stages of pregnancy. Synchronization epochs and phase locking patterns are analyzed at certain synchronization ratios (SRs) for three gestational age groups (16-26 weeks, 27-33 weeks, 34-40 weeks). Results show that the normalized synchronization epoch is significantly different for three age groups with the p-value of 6.72 10-6 and 2.89 10-4 at SR of 1-2 and 4-5 respectively. The variance of phase locking also shows significant difference for three groups with the p-value less than 10-7 at four SRs. Results also suggest that synchronization may be the force behind the increase in the maternal heart rate to maintain the fetal development and provide supplies for the fetus. Overall, the findings propose new clinical markers for evaluating the antenatal development.
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U2 - 10.1109/EMBC.2013.6610377
DO - 10.1109/EMBC.2013.6610377
M3 - Conference contribution
C2 - 24110564
AN - SCOPUS:84886548857
SN - 9781457702167
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 3821
EP - 3824
BT - 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
Y2 - 3 July 2013 through 7 July 2013
ER -