Inverse correlation between CD34 expression and proline-4 hydroxyase immunoreactivity on spindle cells noted in hypertrophic scars and keloids

Setsuya Aiba, Hachiro Tagami

Research output: Contribution to journalArticlepeer-review

78 Citations (Scopus)

Abstract

The CD34 positive (CD34+) spindle cells constitute a special population of spindle cells which show a unique distribution in the skin. So far, however, the functional role of CD34+ spindle cells and the regulation of CD34 expression on dermal spindle cells are totally unknown. We examined immunohistologically the pattern of the expression of CD34 and proline-4-hydroxylase, a marker for the fibroblasts that participate in active collagen synthesis, on dermal spindle cells at various stages of scar and keloidal tissues. Dermal spindle cells in the lesions of hypertrophic scar and those at inflammatory expanding borders of keloids totally lost CD34 expression, but they strongly expressed proline-4-hydroxylase. On the other hand, they expressed CD34, together with decreased immunoreactivity to anti-proline-4-hydroxylase antibody, in non-inflammatory scars or in a non-inflammatory central portion of keloid. In two cases of scars, in which inflammation began to subside, double immunofluorescence demonstrated that both CD34 and proline-4-hydroxylase were expressed on the same spindle cells. CD34 expression, once disappeared from the lesions of hypertrophic scar or keloid, seems to return on CD34-proline-4-hydroxylase+ cells, when the initial inflammatory changes begin to regress. There is a reverse correlation between CD34 expression on spindle cells and the synthesis of type I collagen in the skin.

Original languageEnglish
Pages (from-to)65-69
Number of pages5
JournalJournal of cutaneous pathology
Volume24
Issue number2
DOIs
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology

Fingerprint Dive into the research topics of 'Inverse correlation between CD34 expression and proline-4 hydroxyase immunoreactivity on spindle cells noted in hypertrophic scars and keloids'. Together they form a unique fingerprint.

Cite this