Introduction of translational research in omics science to clinical anesthesia

Shigekazu Sugino, Tomo Hayase, Michiaki Yamakage

Research output: Contribution to journalArticlepeer-review

Abstract

Much progress has been made in omics research following completion of the Human Genome Project. This comprehensive analysis produced a new discipline (i.e., bioinformatics), and its findings contributed to the clinical practice of anesthesiology. Genomes of patients show genetic variations and may predict the sensitivity to anesthetics and analgesics, incidence of adverse effects, and intensity of postsurgical pain. Changes in the transcriptomes of patients may also reflect anesthesia-related expression profiles of various types of neurons in the brain, and information on such changes may contribute to molecular targeted therapy in anesthetized patients. In addition, novel epigenome research may explain why environments change the phenotypes of clinical anesthesia. We currently hypothesize that female gender is associated with DNA methylation in pain-related and vomiting-related gene promoter regions at the genome-wide level and that epigenetic mechanisms are involved in gender differences in anesthesia practice.

Original languageEnglish
Pages (from-to)296-303
Number of pages8
JournalJapanese Journal of Anesthesiology
Volume62
Issue number3
Publication statusPublished - 2013 Mar 1
Externally publishedYes

Keywords

  • Epigenome research
  • Human genome
  • Omics research
  • Transcriptomes

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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