Intravenous immunoglobulin treatment successfully improved subacute progressive polyradiculoneuropathy with polyclonal gammopathy

Kaoru Endo, Naoki Suzuki, Taro Ikenishi, Masashi Aoki, Yasuto Itoyama

Research output: Contribution to journalArticle

Abstract

The present case was an elderly man with a history of gastric cancer, diffuse biliary duct stenosis and liver cirrhosis. He had markedly elevated IgG, suggesting chronic infection or inflammatory changes in the biliary duct. He developed weakness in his arms and became unable to use his hands within one month and 2 weeks later, he had difficulty walking. Based on his progressive disease course, elevated serum IgG, nerve conduction study and enhanced MRI findings, we diagnosed him as suffering from immune-mediated subacute polyradiculoneuropathy with polyclonal gammopathy, which might be related to Guillain-Barré syndrome. Intravenous immunoglobulin (IVIg) was dramatically effective in this patient. In the follow-up 6 months later he was stable and could walk without a cane. Even in patients with polyclonal gammopathy in chronic inflammatory disease of another organ, IVIg may be effective and beneficial for the patients's quality of life.

Original languageEnglish
Pages (from-to)2037-2039
Number of pages3
JournalInternal Medicine
Volume48
Issue number23
DOIs
Publication statusPublished - 2009 Dec 1

Keywords

  • Guillain-Barré-syndrome
  • Intravenous immunoglobulin (IVIg)
  • Polyclonal gammopathy

ASJC Scopus subject areas

  • Internal Medicine

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