Intrauterine environment-genome interaction and children's development (2): Brain structure impairment and behavioral disturbance induced in male mice offspring by a single intraperitoneal administration of domoic acid (DA) to their dams

Kentaro Tanemura, Katsuhide Igarashi, Toshiko R. Matsugami, Ken Ichi Aisaki, Satoshi Kitajima, Jun Kanno

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

To demonstrate induction of delayed central nervous toxicity by disturbing neuronal activities in the developing brain, we administered a single intraperitoneal dose of domoic acid (DA; 1 mg/kg), a potent glutamate receptor agonist, to pregnant female mice at the gestational day of 11.5, 14.5 or 17.5. The dams had recovered from acute symptoms within 24 hr, followed by normal delivery, feeding and weaning. All male offspring mice after weaning were apparently normal in response to handlers during cage maintenance, body weight measurement and to mate mice in group housing conditions. At the age of 11 weeks, our neurobehavior testing battery revealed severe impairment of learning and memory with serious deviances of anxiety-related behaviors. The developed brain of prenatally exposed mice showed myelination failure and the overgrowth of neuronal processes of the limbic cortex neurons. This study indicates that the temporal disturbance of neurotransmission of the developing brain induces irreversible structural and functional damage to offspring which becomes monitorable in their adulthood by a proper battery of neurobehavioral tests.

Original languageEnglish
Pages (from-to)SP279-SP286
JournalJournal of Toxicological Sciences
Volume34
Issue number2 SPEC. ISS.
DOIs
Publication statusPublished - 2009

Keywords

  • Behavior
  • Brain structure
  • Domoic acid
  • Prenatal exposure

ASJC Scopus subject areas

  • Toxicology

Fingerprint Dive into the research topics of 'Intrauterine environment-genome interaction and children's development (2): Brain structure impairment and behavioral disturbance induced in male mice offspring by a single intraperitoneal administration of domoic acid (DA) to their dams'. Together they form a unique fingerprint.

Cite this