Intratumoral aromatase in human breast, endometrial, and ovarian malignancies

Hironobu Sasano, Nobuhiro Harada

Research output: Contribution to journalReview article

196 Citations (Scopus)

Abstract

In human estrogen-dependent neoplasms such as breast, endometrioid endometrial, and surface epithelial-stromal ovarian carcinomas, intratumoral aromatase is considered to play important roles in converting circulating androgens derived from adrenal cortex and/or ovary to estrogens, possibly in association with 17β-HSD type 1 and estrogen sulfatase. Analysis of intratumoral aromatase in these estrogen-dependent neoplasms is important not only in understanding the development and biological behavior of these tumors, but also in the clinical management of these patients, because suppression of intratumoral aromatase by newly developed aromatase inhibitors may provide new potentials in endocrine therapy of these patients.

Original languageEnglish
Pages (from-to)593-607
Number of pages15
JournalEndocrine Reviews
Volume19
Issue number5
DOIs
Publication statusPublished - 1998 Oct 22

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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