Intrarenal angiotensin converting enzyme inhibition in spontaneously hypertensive rats

Hajime Aihara, Hiromi Ogawa, Akira Kasuya, Makoto Yoshida, Mizue Suzuki-Kusaba, Hiroaki Hisa, Susumu Satoh

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

We examined the hypotensive effect of enalapril in relation to the local renin-angiotensin system of the kidney in spontaneously hypertensive rats (SHR). Oral administration of enalapril for 7 days decreased mean arterial blood pressure and renal tissue angiotensin II concentration without affecting plasma angiotensin II concentration in SHR. The enalapril treatment did not affect maximum binding of angiotensin II to renal tubules and glomeruli in SHR. In normotensive Wistar-Kyoto rats, no significant changes in mean arterial blood pressure, renal and plasma angiotensin levels were observed with enalapril treatment. Direct infusion of enalapril into the renal medullary interstitium decreased mean arterial blood pressure in association with the reduction of renal tissue angiotensin II concentration without changes in plasma angiotensin II concentration in SHR. These observations suggest that the inhibition of angiotensin conversion in the kidney is important for the hypotensive action of enalapril.

Original languageEnglish
Pages (from-to)35-40
Number of pages6
JournalEuropean Journal of Pharmacology
Volume373
Issue number1
DOIs
Publication statusPublished - 1999 May 28

Keywords

  • Angiotensin II
  • Hypertension
  • Kidney
  • Spontaneously hypertensive rats (SHR)

ASJC Scopus subject areas

  • Pharmacology

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